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Article

Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function.

The Journal of biological chemistry - 29 Sept 2000

Pabon A, Chan K W, Sui J L, Wu X, Logothetis D E, Thornhill W B

Abstract excerpt

GIRK (G protein-gated inward rectifier K(+) channel) proteins play critical functional roles in heart and brain physiology. Using antibodies directed to either GIRK1 or GIRK4, site-directed mutagenesis, and specific glycosidases, we have investigated the effects of glycosylation in the biosynthesis and heteromerization of these proteins expressed in oocytes. Both GIRK1 and GIRK4 have one extracellular consensus...

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PMID: 10889209
DOI: 10.1074/jbc.M005338200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function.PMID 10889209Read ↗

Identification and characterization of site-specific N-glycosylation in the potassium channel Kv3.1b.Semantic proximity Read ↗

The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype.Semantic proximity Read ↗

A phosphorylation-dependent export structure in ROMK (Kir 1.1) channel overrides an endoplasmic reticulum localization signal.Semantic proximity Read ↗

Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling.Semantic proximity Read ↗

Characterization of N-glycosylation consensus sequences in the Kv3.1 channel.Semantic proximity Read ↗

Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels.Semantic proximity Read ↗

Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane.Semantic proximity Read ↗

A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits.Semantic proximity Read ↗

Conserved extracellular cysteine residues in the inwardly rectifying potassium channel Kir2.3 are required for function but not expression in the membrane.Semantic proximity Read ↗

Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels.Semantic proximity Read ↗

Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation.Semantic proximity Read ↗

Functional properties of a truncated recombinant GIRK5 potassium channel.Semantic proximity Read ↗

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