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Article

Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes.

Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2000

Yashiro K, Saijoh Y, Sakuma R, Tada M, Tomita N, Amano K, Matsuda Y, Monden M, Okada S, Hamada H

Abstract excerpt

BACKGROUND: Mouse lefty1 and lefty2 genes are expressed on the left side of developing embryos and are required for left-right determination. Here we have studied expression and transcriptional regulatory mechanisms of human LEFTY genes. RESULTS: The human LEFTY locus comprises two functional genes (LEFTY1 and LEFTY2) and a putative pseudogene. LEFTY1 is expressed in colon crypts. However, whereas LEFTY1 mRNA is...

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Source

Identifiers

PMID: 10886363
DOI: 10.1046/j.1365-2443.2000.00329.x

Genes

LEFTY1
LEFTY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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