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Immortalisation of human bone marrow endothelial cells: characterisation of new cell lines

1 Jul 2000

Abstract excerpt

BACKGROUND: Adhesion of haematopoietic progenitor cells (HPC) to human bone marrow endothelial cells (HBMEC) plays a key role in homing of HPC to bone marrow. Here we describe four new HBMEC cell lines that can be used to study the (specific) adhesion of HPC to HBMEC. DESIGN: HBMEC were immortalised with a retroviral construct containing the human papilloma virus 16 E6/E7 genes. Four cell lines were...

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PMID: 10886302
DOI: 10.1046/j.1365-2362.2000.00672.x

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