Macrofilaricidal activity of tetracycline against the filarial nematode <i>Onchocerca ochengi</i> : elimination of <i>Wolbachia</i> precedes worm death and suggests a dependent relationship

Abstract excerpt

Filarial nematodes are important and widespread parasites of animals and humans. We have been using the African bovine parasite Onchocerca ochengi as a chemotherapeutic model for O. volvulus, the causal organism of 'river blindness' in humans, for which there is no safe and effective drug lethal to adult worms. Here we report that the antibiotic, oxytetracycline is macrofilaricidal against O. ochengi. In a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Insect symbiosis and bacterial influences
• Share to Nematode management and characterization studies