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An investigation of the rigor of interpretation rules for STRs derived from less than 100 pg of DNA.

Forensic science international - 24 Jul 2000

Gill P, Whitaker J, Flaxman C, Brown N, Buckleton J

Abstract excerpt

By increasing the PCR amplification regime to 34 cycles, we have demonstrated that it is possible routinely to analyse <100 pg DNA. The success rate was not improved (without impairing quality) by increasing cycle number further. Compared to amplification of 1 ng DNA at 28 cycles, it was shown that increased imbalance of heterozygotes occurred, along with an increase in the size (peak area) of stutters. The...

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PMID: 10882828
DOI: 10.1016/s0379-0738(00)00158-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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