Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple Epitopes from the Mycobacterium tuberculosis ESAT-6 Antigen Are Recognized by Antigen-Specific Human T Cell Lines

1 Jun 2000

Abstract excerpt

A synthetic-peptide approach was used to map epitope regions of the Mycobacterium tuberculosis 6-kDa early secreted antigen target (ESAT-6) by testing human CD4(+) T cell lines for secretion of IFN-gamma in response to recombinant ESAT-6 (rESAT-6) and overlapping 20-mer peptides covering the antigen sequence. The results demonstrate that all of the ESAT-6 peptides screened were able to induce IFN-gamma secretion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunodeficiency and Autoimmune Disorders
Share to Immunotherapy and Immune Responses
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10875783
DOI: 10.1086/313862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple Epitopes from the Mycobacterium tuberculosis ESAT-6 Antigen Are Recognized by Antigen-Specific Human T Cell LinesPMID 10875783Read ↗

Human Th1 Cell Lines Recognize the Mycobacterium tuberculosis ESAT‐6 Antigen and its Peptides in Association with Frequently Expressed HLA Class II MoleculesSemantic proximity Read ↗

Immunological Characterization of Proteins Expressed by Genes Located in Mycobacterium tuberculosis-Specific Genomic Regions Encoding the ESAT6-like ProteinsSemantic proximity Read ↗

Antigenic Equivalence of Human T-Cell Responses to Mycobacterium tuberculosis -Specific RD1-Encoded Protein Antigens ESAT-6 and Culture Filtrate Protein 10 and to Mixtures of Synthetic PeptidesSemantic proximity Read ↗

The role of ESAT-6 in tuberculosis immunopathologySemantic proximity Read ↗

Epitope Mapping of the Immunodominant Antigen TB10.4 and the Two Homologous Proteins TB10.3 and TB12.9, Which Constitute a Subfamily of the <i>esat-6</i> Gene FamilySemantic proximity Read ↗

Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2Semantic proximity Read ↗

Screening of Predicted Secreted Antigens fromMycobacterium bovisReveals the Immunodominance of the ESAT-6 Protein FamilySemantic proximity Read ↗

A Novel B-Cell Epitope Identified within Mycobacterium tuberculosis CFP10/ESAT-6 ProteinSemantic proximity Read ↗

Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.Semantic proximity Read ↗

Efficient Testing of Large Pools of Mycobacterium tuberculosis RD1 Peptides and Identification of Major Antigens and Immunodominant Peptides Recognized by Human Th1 CellsSemantic proximity Read ↗

Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B.Semantic proximity Read ↗

Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.