Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of the factor V Leiden mutation on pregnancy.

Human reproduction update - 1 Jan 2000

Spina V, Aleandri V, Morini F

Abstract excerpt

A resistance to the anticoagulant activity of activated protein C (APC), most frequently due to a point mutation in the Factor V gene (the Leiden mutation), represents the most common genetic cause of thrombophilia. The Leiden mutation has been significantly related to pregnancy complications associated with hypercoagulation, e.g. deep vein thrombosis during pregnancy (8-fold increased risk), pre-eclampsia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fetal Death
Share to Fetal Growth Retardation
Share to Placenta Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pre-Eclampsia

Share to Pregnancy Complications, Cardiovascular

Share to Pregnancy Complications, Hematologic

Share to Pregnancy Outcome

Share to Thrombophilia

Source

Identifiers

PMID: 10874575
DOI: 10.1093/humupd/6.3.301

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of the factor V Leiden mutation on pregnancy.PMID 10874575Read ↗

Obstetric implications of activated protein C resistance and factor V Leiden mutation.Semantic proximity Read ↗

The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis.Semantic proximity Read ↗

A possible role for activated protein C resistance in patients with first and second trimester pregnancy failure.Semantic proximity Read ↗

Multiple obstetric complications of factor V Leiden mutation.Semantic proximity Read ↗

Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage.Semantic proximity Read ↗

Factor V Leiden and fetal loss in a 33-year-old Tunisian woman.Semantic proximity Read ↗

Antenatal screening for factor V Leiden mutation: a critical appraisal.Semantic proximity Read ↗

Evolution of Factor V LeidenSemantic proximity Read ↗

Factor V Leiden mutation and pregnancy-related complications.Semantic proximity Read ↗

Activated Protein C Resistance and Factor V Leiden Mutation can be Associated with First‐ as well as Second‐Trimester Recurrent Pregnancy Loss1Semantic proximity Read ↗

Changes of resistance to activated protein C in the course of pregnancy and prevalence of factor V mutation.Semantic proximity Read ↗

Factor V Leiden and prothrombin G20210A mutations in pregnancies with adverse outcome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.