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Article

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

Journal of molecular biology - 7 Jul 2000

Gao H Q, Boyer P L, Sarafianos S G, Arnold E, Hughes S H

Abstract excerpt

Treating HIV infections with drugs that block viral replication selects for drug-resistant strains of the virus. Particular inhibitors select characteristic resistance mutations. In the case of the nucleoside analogs 3TC and FTC, resistant viruses are selected with mutations at amino acid residue 184 of reverse transcriptase (RT). The initial change is usually to M184I; this virus is rapidly replaced by a variant...

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Identifiers

PMID: 10873473
DOI: 10.1006/jmbi.2000.3823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.PMID 10873473Read ↗

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