Article
Liver repopulation after cell transplantation in mice treated with retrorsine and carbon tetrachloride.
Transplantation - 15 Jun 2002
Guo Danqing, Fu Tao, Nelson Jeffery A, Superina Riccardo A, Soriano Humberto E
Abstract excerpt
BACKGROUND: Efficiency of engraftment after liver cell transplantation is less than 1% under conventional conditions. Our aim was to develop a high-efficiency, nonsurgical, no-genetic-advantage mouse model of liver repopulation with transplanted cells. METHODS: Mice were conditioned with nonlethal doses of a cell cycle inhibitor, retrorsine, 70 mg/kg, to irreversibly block proliferation of native hepatocytes....
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