Article
Duplicated DQ haplotypes increase the complexity of restriction element usage in cattle.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2000
Glass E J, Oliver R A, Russell G C
Abstract excerpt
The MHC of cattle encodes two distinct isotypes of class II molecules, DR and DQ. Unlike humans, cattle lack the DP locus and about half the common haplotypes express duplicated DQ genes. The number and frequency of DQA and DQB alleles means that most cattle are heterozygous. If inter- and/or intrahaplotype pairing of DQA and DQB molecules occurs, cattle carrying DQ-duplicated haplotypes may express more...
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