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Article

Comparison of Photodynamic Targets in a Carcinoma Cell Line and Its Mitochondrial DNA-Deficient Derivative

1 Jan 2000

Abstract excerpt

The relative contribution, to cell death, of photodynamic damage to respiratory proteins (known targets of photodynamic therapy with many photosensitizers) and other cellular sites was examined. The models were a human ovarian carcinoma cell line 2008, and its mitochondrial DNA-deficient derivative ET3, which lacks several key respiratory protein subunits. Phototoxicity was compared in the two cell lines with...

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PMID: 10857372
DOI: 10.1562/0031-8655(2000)0710747coptia2.0.co2

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