Article
Lysosomal cathepsin initiates apoptosis, which is regulated by photodamage to Bcl-2 at mitochondria in photodynamic therapy using a novel photosensitizer, ATX-s10 (Na).
International journal of oncology - 1 Aug 2006
Ichinose Shuji, Usuda Jitsuo, Hirata Takeshi, Inoue Tatsuya, Ohtani Keishi, Maehara Sachio, Kubota Mitsuhiro, Imai Kentarou, Tsunoda Yoshihiko, Kuroiwa Yukari, Yamada Kimito, Tsutsui Hidemitsu, Furukawa Kinya, Okunaka Tetsuya, Oleinick Nancy L, Kato Harubumi
Abstract excerpt
ATX-s10 is a novel and second-generation photosensitizer for photodynamic therapy (PDT). In order to conduct clinical trials of ATX-s10-PDT and/or extend its clinical applications, it is very important to elucidate the mechanisms of the action of ATX-s10-PDT. We examined the apoptic response against ATX-s10-PDT using a Bcl-2 or Bcl-2 mutant overexpressing cells. Using fluorescent microscopy, ATX-s10 localized not...
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