Article
Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia.
Atherosclerosis - 1 Jun 2000
Raal F J, Pappu A S, Illingworth D R, Pilcher G J, Marais A D, Firth J C, Kotze M J, Heinonen T M, Black D M
Abstract excerpt
Patients with homozygous familial hypercholesterolaemia (HoFH) have markedly elevated low density lipoprotein (LDL) cholesterol levels that are refractory to standard doses of lipid-lowering drug therapy. In the present study we evaluated the effect of atorvastatin on steady state concentrations of plasma lipids and mevalonic acid (MVA), as well as on 24-h urinary excretion of MVA in patients with well...
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