Article
The 10q25 neocentromere and its inactive progenitor have identical primary nucleotide sequence: further evidence for epigenetic modification.
Genome research - 1 Jun 2000
Barry A E, Bateman M, Howman E V, Cancilla M R, Tainton K M, Irvine D V, Saffery R, Choo K H
Abstract excerpt
We have previously localized the core centromere protein-binding domain of a 10q25.2-derived neocentromere to an 80-kb genomic region. Detailed analysis has indicated that the 80-kb neocentromere (NC) DNA has a similar overall organization to the corresponding region on a normal chromosome 10 (HC) DNA, derived from a genetically unrelated CEPH individual. Here we report sequencing of the HC DNA and its comparison...
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