Article
Interstitial deletion of proximal 8q including part of the centromere from unbalanced segregation of a paternal deletion/marker karyotype with neocentromere formation at 8p22.
Cytogenetic and genome research - 1 Jan 2011
Burnside R D, Ibrahim J, Flora C, Schwartz S, Tepperberg J H, Papenhausen P R, Warburton P E
Abstract excerpt
BACKGROUND/AIMS: The 'McClintock mechanism' of chromosome breakage and centromere misdivision, in which a deleted chromosome with its concomitant excised marker or ring chromosome is formed, has been described in approximately one dozen reports. We report a case of a girl with short stature, developmental delay, and dysmorphic features. METHODS: Analysis was performed on the proband and father using cytogenetic...
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