Article
Analysis of CYP21 coding polymorphisms in three ethnic populations: further evidence of nonamplifying CYP21 alleles among whites.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Mar 2000
Ozturk I C, Wei W L, Palaniappan L, Rubenfire M, Killeen A A
Abstract excerpt
BACKGROUND: Adrenal steroid 21-hydroxylase is essential for the synthesis of both mineralocorticoids and glucocorticoids. The gene for this enzyme, CYP21, contains several frequent coding polymorphisms. Because of its essential function in steroid synthesis, polymorphisms in this enzyme might influence a variety of disease processes. However, before disease-association studies are performed, it is important to...
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