Article
Molecular pathogenesis of muscle degeneration in the delta-sarcoglycan-deficient hamster.
The American journal of pathology - 1 Nov 1998
Straub V, Duclos F, Venzke D P, Lee J C, Cutshall S, Leveille C J, Campbell K P
Abstract excerpt
The BIO14.6 hamster is an extensively used animal model of autosomal recessive cardiomyopathy and muscular dystrophy. Recently, a large deletion in the 5' end of the delta-sarcoglycan gene was found to be the primary genetic defect in the hamster. In the present investigation, we studied the effe...
Topics
- Animals
- Cardiomyopathies
- Cricetinae
- Cytoskeletal Proteins
- Disease Models, Animal
- Dystroglycans
- Dystrophin
- Female
- Immunohistochemistry
- Macromolecular Substances
- Male
- Membrane Glycoproteins
- Mesocricetus
- Muscle Fibers, Skeletal
- Muscle, Skeletal
- Mutation
- Myocardium
- Sarcoglycans