Article
Molecular pathogenesis of muscle degeneration in the delta-sarcoglycan-deficient hamster.
The American journal of pathology - 1 Nov 1998
Straub V, Duclos F, Venzke D P, Lee J C, Cutshall S, Leveille C J, Campbell K P
Abstract excerpt
The BIO14.6 hamster is an extensively used animal model of autosomal recessive cardiomyopathy and muscular dystrophy. Recently, a large deletion in the 5' end of the delta-sarcoglycan gene was found to be the primary genetic defect in the hamster. In the present investigation, we studied the effects of the delta-sarcoglycan deletion on transcription, expression, and function of the dystrophin-glycoprotein complex...
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