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Article

HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnancies

1 Jun 2000

Abstract excerpt

Human leukocyte antigen (HLA)-G is a major histocompatibility gene expressed almost exclusively in extravillous trophoblasts at the fetal-maternal interface. HLA-G may play a role in protecting the fetus from attack by the maternal natural killer cells. The extravillous trophoblasts invade the decidua and maternal spiral arteries. The factors which regulate the cell-specific expression of HLA-G are unknown. In...

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Share to Ectopic Pregnancy Diagnosis and Management
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PMID: 10825371
DOI: 10.1093/molehr/6.6.535

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Related research

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Click a neighbor to travelStep 1 · 12 closest

HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnanciesPMID 10825371Read ↗

Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytesSemantic proximity Read ↗

Human leukocyte antigens: the unique expression in trophoblasts and their crosstalk with local immune cellsSemantic proximity Read ↗

Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory propertiesSemantic proximity Read ↗

Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsiaSemantic proximity Read ↗

Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.Semantic proximity Read ↗

The soluble pool of HLA-G produced by human trophoblasts does not include detectable levels of the intron 4-containing HLA-G5 and HLA-G6 isoformsSemantic proximity Read ↗

Identification of a Thymic Epithelial Cell Subset Sharing Expression of the Class Ib HLA-G Molecule with Fetal TrophoblastsSemantic proximity Read ↗

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysisSemantic proximity Read ↗

Amnion Epithelial Cells, in Contrast to Trophoblast Cells, Express All Classical HLA Class I Molecules Together With HLA‐GSemantic proximity Read ↗

HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal NicheSemantic proximity Read ↗

Role of the HLA-G immune checkpoint molecule in pregnancy.Semantic proximity Read ↗

Definitive class I human leukocyte antigen expression in gestational placentation: <scp>HLA</scp> ‐F, <scp>HLA</scp> ‐E, <scp>HLA</scp> ‐C, and <scp>HLA</scp> ‐G in extravillous trophoblast invasion on placentation, pregnancy, and parturitionSemantic proximity Read ↗

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