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Article

Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia

1 Jan 2000

Abstract excerpt

Pre-eclampsia, a common complication of first pregnancies, is thought to result from a poorly perfused placenta and may reflect an abnormal maternal immune reaction to the hemiallogenic fetus. Human leukocyte antigen (HLA)-G, a major histocompatibility tissue-specific antigen expressed in extravillous trophoblast cells (fetal-derived), may protect trophoblasts from maternal-fetal immune intolerance and allow...

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PMID: 10611266
DOI: 10.1093/molehr/6.1.88

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Related research

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Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsiaPMID 10611266Read ↗

HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnanciesSemantic proximity Read ↗

Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population.Semantic proximity Read ↗

Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease.Semantic proximity Read ↗

Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory propertiesSemantic proximity Read ↗

Role of Human Leukocyte Antigens at the Feto-Maternal Interface in Normal and Pathological Pregnancy: An UpdateSemantic proximity Read ↗

Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytesSemantic proximity Read ↗

HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels.Semantic proximity Read ↗

HLA-G*0105N null allele encodes functional HLA-G isoforms.Semantic proximity Read ↗

HLA-G and pregnancy.Semantic proximity Read ↗

Human leukocyte antigens: the unique expression in trophoblasts and their crosstalk with local immune cellsSemantic proximity Read ↗

Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.Semantic proximity Read ↗

The soluble pool of HLA-G produced by human trophoblasts does not include detectable levels of the intron 4-containing HLA-G5 and HLA-G6 isoformsSemantic proximity Read ↗

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