Article
Expression of c-kit and kit-ligand in benign and malignant prostatic tissues.
Histology and histopathology - 1 Apr 2000
Simak R, Capodieci P, Cohen D W, Fair W R, Scher H, Melamed J, Drobnjak M, Heston W D, Stix U, Steiner G, Cordon-Cardo C
Abstract excerpt
The tyrosine kinase receptor c-kit and its ligand [kit ligand (KL) or stem cell factor (SCF)] exert a broad range of biological activities during organogenesis and normal cell development. Recent studies have revealed that altered c-kit levels occur in a variety of malignancies and cancer cell lines. KL has also been shown to stimulate the growth of malignant cells, as well as to promote chemotaxis. We had...
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