Article
A Japanese propositus with D-- phenotype characterized by the deletion of both the RHCE gene and D1S80 locus situated in chromosome 1p and the existence of a new CE-D-CE hybrid gene.
Journal of human genetics - 1 Jan 2000
Okuda H, Fujiwara H, Omi T, Iwamoto S, Kawano M, Ishida T, Nomura S, Fukuhara S, Nagai A, Ohya I, Kajii E
Abstract excerpt
In a family study of a Japanese propositus with the D-- phenotype, the serological data of her D-- phenotype and those of her parents were discrepant. Gene analysis of the propositus showed a gross deletion of the RHCE gene and a new rearrangement of RHCE to yield the CE-D-CE hybrid. It was demonstrated that the hybrid CE-D-CE gene consisted of exon 1 from the RHCE gene, followed by exons 3 to 7 from the RHD gene...
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