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Article

RH gene inversion-recombination as a major mechanism of the D phenotype in China.

Blood transfusion = Trasfusione del sangue - 1 Jan 2026

Ying Yanling, Zhang Jingjing, Hong Xiaozhen, Yuan Wenjing, Zhang Bing, Huang Xinyu, Xu Xianguo, Zhu Faming

Abstract excerpt

BACKGROUND: The D-- phenotype is an extremely rare RhCE variant characterized by the complete absence of RhCE antigens in the Rh blood group system and is associated with a highly complex molecular mechanism. In this study, several D-- individuals with discrepancies between phenotypic and genotypic results were analyzed, and a complex RH gene inversion-recombination variant with a novel breakpoint was identified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41481569
DOI: 10.2450/BloodTransfus.1095
PMCID: PMC12962860

Genes

RHCE
RHAG
RHD
TMEM50A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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