Article
An actin subdomain 2 mutation that impairs thin filament regulation by troponin and tropomyosin.
The Journal of biological chemistry - 21 Jul 2000
Korman V L, Hatch V, Dixon K Y, Craig R, Lehman W, Tobacman L S
Abstract excerpt
Striated muscle thin filaments adopt different quaternary structures, depending upon calcium binding to troponin and myosin binding to actin. Modification of actin subdomain 2 alters troponin-tropomyosin-mediated regulation, suggesting that this region of actin may contain important protein-protein interaction sites. We used yeast actin mutant D56A/E57A to examine this issue. The mutation increased the affinity...
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