Article
Well-differentiated villoglandular adenocarcinoma of the uterine cervix: oncogene/tumor suppressor gene alterations and human papillomavirus genotyping.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Apr 2000
Jones M W, Kounelis S, Papadaki H, Bakker A, Swalsky P A, Woods J, Finkelstein S D
Abstract excerpt
Twelve well-differentiated villoglandular adenocarcinomas (WDVAs) of the uterine cervix were retrospectively analyzed for the presence and specific genotype of human papillomavirus (HPV), tumor suppressor loss (p53, MCC, APC, BRCA1), cancer gene mutation (K-ras-2, exons 1 and 2, p53 exons 5 to 8), and oncogene amplification (c-erbB-2/HER-2/neu, int-2). Tissue for genetic evaluation was obtained by...
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