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Article

An improved <i>in vitro</i> bioassay for the study of 5‐HT<sub>4</sub> receptors in the human isolated large intestinal circular muscle

1 Apr 2000

Abstract excerpt

Recently, it was demonstrated that 5-HT induces relaxation of human colon circular muscle through activation of 5-HT(4) receptors and 5-HT(7) receptors. The aim of the current study was to develop a new in vitro bioassay of human colon that would facilitate the pharmacological analysis of 5-HT responses mediated solely by 5-HT(4) receptors. Contracting circular muscle strips with KCl (80 mM) yielded a stable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10780964
DOI: 10.1038/sj.bjp.0703254

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