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Article

Expression of the <i>Sonic Hedgehog</i> gene in human embryos with neural tube defects

13 Apr 2000

Abstract excerpt

BACKGROUND: To estimate the rate of malformations observed during early human development, a series of 38,913 first-trimester abortions were studied. Neural tube defects (NTD) were found in 57 cases. METHODS: A histological study of serial sections performed in 25 embryos revealed a spectrum of axial structure abnormalities. Expression of the SHH gene was studied by in situ hybridization in one case of CRS and in...

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PMID: 10777830
DOI: 10.1002/(sici)1096-9926(200005)61:5<347::aid-tera6>3.0.co;2-#

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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