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Article

Three-dimensional clustering of human RAG2 gene mutations in severe combined immune deficiency.

The Journal of biological chemistry - 28 Apr 2000

Corneo B, Moshous D, Callebaut I, de Chasseval R, Fischer A, de Villartay J P

Abstract excerpt

The V(D)J recombination, which leads to the somatic rearrangement of variable, diversity, and joining segments, is the mechanism accountable for the diversity of T cell receptor- and Ig-encoding genes. The products of the RAG1 and RAG2 genes are the lymphoid-specific factors responsible for the initiation of the V(D)J recombination through the generation of a DNA double strand break. RAG1 or RAG2 gene...

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Source

Identifiers

PMID: 10777560
DOI: 10.1074/jbc.275.17.12672

Genes

RAG2
RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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