Article
HLA haplotypes are associated with differential susceptibility to Trypanosoma cruzi infection.
Tissue antigens - 1 Mar 2000
Nieto A, Beraún Y, Collado M D, Caballero A, Alonso A, González A, Martín J
Abstract excerpt
We explored a possible role of HLA class II genes in determining the susceptibility to Trypanosoma cruzi infection as well as in the development of chagasic heart disease in a rural mestizo population from Arequipa (Southern Peru). HLA-DRB1 and DQB1 polymorphisms were determined in 85 seropositive (asymptomatic, n=52; cardiomyopathic, n=33) and 87 seronegative individuals. We observed that the DRB1*14-DQB1*0301...
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