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Article

Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges.

Journal of molecular biology - 5 May 2000

Albeck S, Unger R, Schreiber G

Abstract excerpt

An experimental approach to evaluate the net binding free energy of buried hydrogen bonds and salt bridges is presented. The approach, which involves a modified multiple-mutant cycle protocol, was applied to selected interactions between TEM-1-beta-lactamase and its protein inhibitor, BLIP. The selected interactions (two salt bridges and two hydrogen bonds) all involving BLIP-D49, define a distinct binding unit....

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Identifiers

PMID: 10772866
DOI: 10.1006/jmbi.2000.3656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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