Article
On the classes of aminoacyl-tRNA synthetases and the error minimization in the genetic code.
Journal of theoretical biology - 7 May 2000
Cavalcanti A R, Neto B D, Ferreira R
Abstract excerpt
As a consequence of the existence of two classes of aminoacyl-tRNA synthetases (aaRSs), we defined two types of mutations: g (mutations that do not change the class of the involved amino acids) and u (those which change the class). We have found that the mean chemical distance resulting from g mutations is smaller than that corresponding to u mutations, indicating that g mutations are responsible for most of the...
Topics
- Amino Acids
- Amino Acyl-tRNA Synthetases
- Animals
- Codon
- Genetic Code
- Humans
- Models, Genetic
- Mutation
- Mutation, Missense
- Point Mutation