Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-1-beta, tumor necrosis factor-alpha, insulin secretion and oral glucose tolerance in non-diabetic siblings of children with IDDM.

Indian journal of pediatrics - 1 Jan 2000

el-Nawawy A, Soliman T, el-Azzouni O, Abbassy A A, Massoud M N, Marzouk S, Ibrahim F, Helal L

Abstract excerpt

Recent reports suggest that the pancreas participates in tumor necrosis factor alpha (TNF-A) production during stress, and that the islets are predominantly responsible for such synthesis. In vitro TNF-A and interleukin 1-beta (IL-1-beta) inhibit insulin release from islet beta-cells. We measured the circulating levels of IL-1-beta, TNF-A and islet cell antibody (ICA) in 30 children with IDDM (10 of them at their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Tolerance Test

Share to Insulin

Share to Interleukin-1

Share to Nuclear Family

Share to Risk Factors

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 10771998
DOI: 10.1007/BF02761143

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Interleukin-1-beta, tumor necrosis factor-alpha, insulin secretion and oral glucose tolerance in non-diabetic siblings of children with IDDM.PMID 10771998Read ↗

Prevalence of islet cell antibodies and its correlation with glucose and insulin response to oral glucose tolerance test in 1st degree relatives of insulin dependent diabetes mellitus probands.Semantic proximity Read ↗

Low serum TNF-alpha levels in subjects at risk for type 1 diabetes.Semantic proximity Read ↗

High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes.Semantic proximity Read ↗

Influence of metabolic and genetic factors on tumour necrosis factor-alpha and lymphotoxin-alpha production in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects.Semantic proximity Read ↗

[The level of circulating cytokines and chemokines in the preclinical and early clinical stages of type IA diabetes mellitus development].Semantic proximity Read ↗

Onset of type 1 diabetes: a dynamical instability.Semantic proximity Read ↗

A Tumour Necrosis Factor Beta Gene Polymorphism in Relation to Monokine Secretion and Insulin‐Dependent Diabetes MellitusSemantic proximity Read ↗

Insulin and the prevention of insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Increase of Neutrophil Extracellular Traps, Mitochondrial DNA and Nuclear DNA in Newly Diagnosed Type 1 Diabetes Children but Not in High-Risk ChildrenSemantic proximity Read ↗

Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.