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Article

Esophagogastric adenocarcinoma in an E1A/E1B transgenic model involves p53 disruption.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Jan 2000

Duncan M D, Tihan T, Donovan D M, Phung Q H, Rowley D L, Harmon J W, Gearhart P J, Duncan K L

Abstract excerpt

We studied tumorigenesis and p53 immunostaining in a murine transgenic model introducing E1A/E1B under the control of the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promoter in which adenocarcinoma occurs at the squamocolumnar junction in the foregut, predominantly in males, and at no other site. Mutations of p53 are frequent in human esophageal adenocarcinoma and the E1B gene product interferes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10769092
DOI: 10.1016/s1091-255x(00)80078-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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