The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation.

Abstract excerpt

It is believed that most malignancies become more common with increasing age due to the requirement for several mutations to accumulate and subsequently interact. The age specific incidence of acute promyelocytic leukemia (APL) was investigated using population-based data from 77 million subject years of observation, yielding 149 consecutive cases. The incidence appears approximately constant with respect to age,...

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