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Intranasal immunization with CPAF combined with cyclic-di-AMP induces a memory CD4 T cell response and reduces bacterial burden following intravaginal infection with <i>Chlamydia muridarum</i>

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection globally, and a vaccine is urgently needed to stop transmission and disease. Chlamydial Protease Activity Factor (CPAF) is an immunoprevalent and immunodominant antigen for CD4 T cells and B cells, which makes it a strong vaccine candidate. Due to the tolerogenic nature of the female genital tract (FGT) and it...

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Literature Corpus work
5d99808c-f481-5fd8-8356-859603bb2723
DOI
10.1101/2024.09.20.614154
Open publication

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Intranasal immunization with CPAF combined with cyclic-di-AMP induces a memory CD4 T cell response and reduces bacterial burden following intravaginal infection with <i>Chlamydia muridarum</i>DOI 10.1101/2024.09.20.614154
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