The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age.

doi:10.1086/302844

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Article

The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age.

American journal of human genetics - 1 Apr 2000

Calloway C D, Reynolds R L, Herrin G L, Anderson W W

Abstract excerpt

An immobilized sequence-specific oligonucleotide (SSO) probe system consisting of 16 SSO probes that detect sequence polymorphisms within five regions of the mtDNA control region was used to investigate the frequency of heteroplasmy in human mtDNA. Five regions of hypervariable region II (HVII) of the control region were studied in blood-, muscle-, heart-, and brain-tissue samples collected from 43 individuals...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Aging
Base Sequence
Brain
Chi-Square Distribution
Child
DNA Mutational Analysis
DNA, Mitochondrial
Equipment Contamination
Gene Frequency
Genetic Variation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Molecular Probe Techniques

Muscles

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Identifiers

PMID: 10739761
DOI: 10.1086/302844
PMCID: PMC1288202

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