Article
Screening for azathioprine toxicity: a pharmacoeconomic analysis based on a target case.
Journal of the American Academy of Dermatology - 1 Apr 2000
Tavadia S M, Mydlarski P R, Reis M D, Mittmann N, Pinkerton P H, Shear N, Sauder D N
Abstract excerpt
The risk of azathioprine-induced myelosuppression can be predicted by detecting patients with intermediate or low thiopurine methyltransferase (TPMT) activity. Population studies have shown that 89% of whites have high TPMT activity, 11% have intermediate TPMT activity, and 0.3% have low TPMT activity. Three specific mutations in the TPMT gene that cause decreased TPMT activity have recently been identified....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.