Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Apr 2000

Heep M, Rieger U, Beck D, Lehn N

Abstract excerpt

A clinical isolate of Helicobacter pylori that developed resistance to rifabutin during therapy carried an rpoB gene that retained a wild-type cluster region sequence but had acquired a novel codon 149 (V149F) mutation. In transformation experiments, the mutation was shown to confer high-level rifabutin resistance. The equivalent mutation (V176F) was present in several resistant isolates of Mycobacterium...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance

Share to Helicobacter pylori

Share to Mycobacterium tuberculosis

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 10722516
DOI: 10.1128/AAC.44.4.1075-1077.2000
PMCID: PMC89817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis.PMID 10722516Read ↗

Mutations at four distinct regions of the rpoB gene can reduce the susceptibility of Helicobacter pylori to rifamycins.Semantic proximity Read ↗

Molecular characterization of Helicobacter pylori resistance to rifamycins.Semantic proximity Read ↗

Characterization of rifampicin-resistant clinical Helicobacter pylori isolates from Germany.Semantic proximity Read ↗

Detection of rifabutin resistance and association of rpoB mutations with resistance to four rifamycin derivatives in Helicobacter pylori.Semantic proximity Read ↗

Rifampin and Rifabutin Resistance Mechanism in <i>Helicobacter pylori</i>Semantic proximity Read ↗

Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates.Semantic proximity Read ↗

Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency.Semantic proximity Read ↗

RifR mutations in the beginning of the Escherichia coli rpoB gene.Semantic proximity Read ↗

Rifampicin resistance and mutation of the<i>rpoB</i>gene in<i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Identification of a 23S rRNA Gene Mutation in Clarithromycin‐Resistant Helicobacter pyloriSemantic proximity Read ↗

Isolation of rifampin-resistant mutants of Listeria monocytogenes and their characterization by rpoB gene sequencing, temperature sensitivity for growth, and interaction with an epithelial cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.