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Article

Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.

Neuron - 1 Feb 2000

Jensen K B, Dredge B K, Stefani G, Zhong R, Buckanovich R J, Okano H J, Yang Y Y, Darnell R B

Abstract excerpt

We have combined genetic and biochemical approaches to analyze the function of the RNA-binding protein Nova-1, the paraneoplastic opsoclonus-myoclonus ataxia (POMA) antigen. Nova-1 null mice die postnatally from a motor deficit associated with apoptotic death of spinal and brainstem neurons. Nova-1 null mice show specific splicing defects in two inhibitory receptor pre-mRNAs, glycine alpha2 exon 3A (GlyRalpha2...

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Identifiers

PMID: 10719891
DOI: 10.1016/s0896-6273(00)80900-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.PMID 10719891Read ↗

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