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Article

Determination and augmentation of RNA sequence specificity of the Nova K-homology domains.

Nucleic acids research - 1 Jan 2004

Musunuru Kiran, Darnell Robert B

Abstract excerpt

The Nova onconeural antigens are implicated in the pathogenesis of paraneoplastic opsoclonus-myoclonus-ataxia (POMA). The Nova antigens are neuron-specific RNA-binding proteins harboring three repeats of the K-homology (KH) motif; they have been implicated in the regulation of alternative splicing of a host of genes involved in inhibitory synaptic transmission. Although the third Nova KH domain (KH3) has been...

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Identifiers

PMID: 15367696
DOI: 10.1093/nar/gkh799
PMCID: PMC519101

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Determination and augmentation of RNA sequence specificity of the Nova K-homology domains.PMID 15367696Read ↗

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Molecular insights into the coding region determinant-binding protein-RNA interaction through site-directed mutagenesis in the heterogeneous nuclear ribonucleoprotein-K-homology domains.Semantic proximity Read ↗

Highly clustered <i>de novo</i> frameshift variants in the neuronal splicing factor <i>NOVA2</i> result in a specific abnormal C terminal part and cause a severe form of intellectual disability with autistic featuresSemantic proximity Read ↗

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