Article
Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby's fundus dystrophy or retinitis pigmentosa.
The British journal of ophthalmology - 1 Nov 1998
Fariss R N, Apte S S, Luthert P J, Bird A C, Milam A H
Abstract excerpt
BACKGROUND/AIMS: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is normally synthesised by the retinal pigment epithelium (RPE) and deposited in Bruch's membrane. Mutations in the TIMP3 gene cause Sorsby's fundus dystrophy (SFD), which is characterised by thickening of Bruch's membrane, choroi...
Topics
- Aged
- Aged, 80 and over
- Bruch Membrane
- Choroid
- Epithelial Cells
- Eye
- Female
- Humans
- Mutation
- Periodic Acid-Schiff Reaction
- Retina
- Retinal Vessels
- Retinitis Pigmentosa
- Tissue Inhibitor of Metalloproteinase-3