Article
Analysis of the collagen VI assemblies associated with Sorsby's fundus dystrophy.
Journal of structural biology - 1 Jan 2000
Knupp Carlo, Chong N H Victor, Munro Peter M G, Luthert Philip J, Squire John M
Abstract excerpt
Age-related macular degeneration is the leading cause of blindness in the Western world, and the pathophysiology of the condition is largely unknown. However, it shares many clinical and pathological features with Sorsby's fundus dystrophy (SFD), an autosomal dominant disease, known to be associated with mutations in the TIMP-3 gene. In Bruch's membrane of both conditions, there are molecular assemblies with...
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