Article
Somatic mutations and genetic polymorphisms of the PPP1R3 gene in patients with several types of cancers.
Oncogene - 10 Feb 2000
Takakura S, Kohno T, Shimizu K, Ohwada S, Okamoto A, Yokota J
Abstract excerpt
Recently, we found nonsense and missense mutations of the PPP1R3 (protein phosphatase 1, regulatory subunit 3) gene in diverse human cancer cell lines and primary lung carcinomas, indicating that PPP1R3 functions as a tumor suppressor in human carcinogenesis. In this study, to assess the prevalence of PPP1R3 mutations in human primary cancers and the genetic diversity of the PPP1R3 gene in the human population,...
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