Article
Taxotere activates transcription factor AP-1 in association with apoptotic cell death in gastric cancer cell lines.
Anticancer research - 1 Jan 2000
Kim R, Ohi Y, Inoue H, Toge T
Abstract excerpt
We investigated whether a novel mitotic inhibitor, taxotere can activate the transcription factor AP-1 in association with apoptotic cell death in 8 gastric cancer cell lines. Apoptotic cell death was analyzed by DNA ladder formation assay, and AP-1 binding activity was assessed by gel mobility-shift assay. The activation of AP-1 binding was induced in accordance with the sensitivity to taxotere in gastric cancer...
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