Article
A rapid one-stage whole-blood HPA-1a phenotyping assay using a recombinant monoclonal IgG1 anti-HPA-1a.
British journal of haematology - 1 Feb 2000
Garner S F, Smethurst P A, Merieux Y, Aeby C, Smith G, Armour K L, Scott M L, Williamson L M, Metcalfe P, Goodall A H, Clark M R, Rigal D, Schawaller M, Ouwehand W H
Abstract excerpt
Severe neonatal alloimmune thrombocytopenia and patients with HPA-1a-specific antibodies require transfusion of HPA-1a-negative platelets. Identifying HPA-1a-negative donors requires simple and reliable typing methods. Most existing techniques use polyclonal antibodies, are time consuming and involve platelet isolation. We have used a horseradish peroxidase (HRP)-conjugated recombinant IgG1 anti-HPA-1a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.