Article
Rapid phenotyping of HPA-1a using either diabody-based hemagglutination or recombinant IgG1-based assays.
Transfusion - 1 Jul 1999
Watkins N A, Armour K L, Smethurst P A, Metcalfe P, Scott M L, Hughes D L, Smith G A, Williamson L M, Clark M R, Ouwehand W H
Abstract excerpt
BACKGROUND: The HPA-1 system is carried on the beta3 integrin. HPA-1a (Zw(a), Pl(A1)) is immunogenic in an HPA-1b homozygote (HPA-1b1b). In pregnancy, 1 of 365 women forms anti-HPA-1a, which causes severe thrombocytopenia in 1 in 1100 neonates. Identification of women at risk of forming anti-HPA-1a and the screening of donors to obtain HPA-1a-negative platelets for therapy need reliable, low-cost, automated...
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