Article
Analysis of genetic polymorphisms at the interleukin-10 and tumour necrosis factor loci in early-onset periodontitis.
Journal of periodontal research - 1 Oct 1999
Kinane D F, Hodge P, Eskdale J, Ellis R, Gallagher G
Abstract excerpt
Early onset periodontitis (EOP) is considered to have a substantial genetic basis, although the gene or genes involved have not been elucidated. The aim of the present study was to investigate possible links between generalized EOP (GEOP) and genes regulating expression of the cytokines tumour necrosis factor (TNF) and interleukin-10 (IL-10). Microsatellite marker DNA sequences corresponding to phenotypic...
Topics
- Adult
- Aggressive Periodontitis
- Alleles
- Case-Control Studies
- Chromosome Mapping
- Gene Expression Regulation
- Genetic Linkage
- Genetic Variation
- Genotype
- Humans
- Interleukin-10
- Microsatellite Repeats
- Monte Carlo Method
- Periodontitis
- Phenotype
- Polymorphism, Genetic
- Sequence Analysis, DNA
- Tumor Necrosis Factor-alpha