Article
CD95-related apoptotic machinery is functional in pancreatic cancer cells.
Pancreas - 1 May 2001
Glazyrin A L, Adsay V N, Vaitkevicius V K, Sarkar F H
Abstract excerpt
The CD95 (FAS, Apo-1) system is a major death pathway in normal and tumor cells. Recent evidence indicates that pancreatic cancer cells express CD95R and CD95L but are insensitive to CD95-mediated apoptosis. Here we show that treatment of human pancreatic cancer cells with RNA synthesis inhibitor actinomycin D (ActD) converted the phenotype of cancer cells from CD95 resistant to CD95 sensitive. Flow cytometric...
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