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Induction of apoptosis by human amylin in RINm5F islet β‐cells is associated with enhanced expression of p53 and p21<sup>WAF1/CIP1</sup>

23 Jul 1999

Abstract excerpt

Human amylin (10 microM) significantly inhibited RINm5F islet beta-cell proliferation and evoked apoptosis associated with typical degenerative ultrastructural changes and DNA fragmentation, whereas rat amylin did not. Time course analysis showed that human amylin elicited apoptosis in a passage-dependent manner. Expression of the apoptosis-related genes p53, bcl-2 and WAF1/CIP1 was examined using Northern blots....

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PMID: 10437796
DOI: 10.1016/s0014-5793(99)00894-7

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