Article
Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus.
Human cell - 1 Sept 2002
Sunamura Makoto, Oonuma Masaru, Motoi Fuyuhiko, Abe Hisashi, Saitoh Yukoh, Hoshida Toru, Ottomo Shigeru, Horii Akira, Matsuno Seiki
Abstract excerpt
In order to develop an effective therapeutic intervention for patients with pancreatic cancer, we examined the genetic alternations of pancreatic cancer. Based on these results, we are developing a new gene therapy targeting the genetic character of pancreatic cancer using mutant adenoviruses selectively replication-competent in tumor cells. Loss of heterozygosity (LOH) of 30% or more were observed on chromosome...
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