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Phase I trial of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy for the treatment of metastatic pancreatic cancer

2 Dec 2020

Abstract excerpt

The safety of oncolytic adenovirus-mediated suicide and interleukin-12 ( IL12 ) gene therapy was evaluated in metastatic pancreatic cancer patients. In this phase I study, a replication-competent adenovirus (Ad5-yCD/ mut TK SR39 rep -hIL-12) expressing yCD/ mut TK SR39 (yeast cytidine deaminase/mutant S39R HSV-1 thymidine kinase) and human IL-12 ( IL12 ) was injected into tumors of 12 subjects with metastatic...

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PMID: 33575474
DOI: 10.1016/j.omto.2020.11.006

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